地点: 美国 发布时间:2013-09-17 01:08:04 |
Transformation of epithelial cells results in a localized benign tumor. During later stage of tumor progression, some tumor cells become invasive and metastatic by transiently turning on an embryonic program called “epithelial mesenchymal transition” (EMT). Tumor cells that underwent an EMT appear mesenchymal, become highly migratory and invasive. A number of transcription factors, which include FOXC2, Twist, Snail, Goosecoid, Slug, and SIP1 regulates EMT process. We found, inhibition of either FOXC2 or Twist expression completely suppressed the metastatic spread in mouse mammary tumor model. This illustrates the importance of the transcription factors capable of inducing EMT and the EMT process in regulating metastasis. Our laboratory is interested in understanding the role of number of these transcription factors during cancer progression. We use variety of in vitro and in vivo tumor models, tissue specific inducible transgenic mouse models to understand this lethal disease. We are looking for self-motivated, bright and independent individuals with a Ph.D. in any area of biomedical sciences are encouraged to apply. In addition, experience in cancer cell biology, developmental biology or stem cells will be a plus point. Competitive Salary and excellent work environment will be provided. Send CV and names of three references to:
Ms. Marie Everett Sr. Administrative Assistant “On behalf of” Dr. Sendurai Mani The Univ. of TX. MD Anderson Cancer Center Dept. of Molecular Pathology, Unit 951 7435 Fannin, Houston, TX 77054 Phone: (713) 834-6031 e-mail: mihernandez@mdanderson.org
|
|
|
|
|
|
|
|