地点: 美国 发布时间:2013-09-17 01:01:22 |
A postdoctoral fellow position is available in Dr. Giorgio Lagna’s group in the Molecular Cardiology Research Institute of Tufts Medical Center, Boston. The lab investigates the action of TGF? and Bone Morphogenetic Proteins (BMP) on the cardiovascular system, with special emphasis on the differentiation of vascular smooth muscle cells. We are particularly seeking someone to help us elucidate the molecular signaling pathways that specifically direct smooth muscle differentiation, and the enthusiasm to extend these findings to in vivo disease models.
Applicants should have a PhD, MD, or both, with a strong background in cell signaling and experience with primary cell culture and in the handling of mice. Training will emphasize interdisciplinary relationships between molecular biology, gene expression, cell signaling and cardiovascular pharmacology and physiology.
Relevant Publications:
1. Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.
J Biol Chem. 2007 Dec 21;282(51):37244-55.
2. Lagna G, Nguyen PH, Ni W, Hata A. BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.
Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1059-67.
3. Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J. Partnership between DPC4 and SMAD proteins in TGF-beta signaling pathways.
Nature. 1996 Oct 31;383(6603):832-6.
Please forward your cover letter and resume to:
Director, Administration and Finance
Molecular Cardiology Research Institute
Tufts-New England Medical Center
750 Washington Street, Box 312
Boston, MA 02111
Or via email to:
dslater@tufts-nemc.org
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