The Danish Centre for Epigenetics is seeking a highly motivated postdoctoral fellow or PhD student to the group of Associate Prof. Morten Frödin at BRIC, University of Copenhagen. Research in our group focuses on cellular regulation and signal transduction via protein kinase cascades, in particular those activated by the RAS and PI3 kinase proto-oncogenes. Please, read more about BRIC and our research on www.bric.dk. The Danish Centre for Epigenetics was established in 2007 on a grant from the Danish National Research Foundation and combines the expertise of 4 laboratories, three of them located at BRIC.
Research area of the present position
The relatively new research field of Epigenetics studies how a multitude of diverse proteins controls the structure of DNA to regulate gene expression. Epigenetic mechanisms are fundamental for normal development and cell function and diseases like cancer. The present projects aim to discover how extra-cellular signals such as growth/differentiation/survival factors utilize protein kinase cascades to induce regulatory phosphorylations in chromatin proteins to ultimately control epigenetic regulation of gene expression and cell function.
One focus will be to investigate how RAS-activated protein kinases exert epigenetic control of gene expression in epithelial cells and how this contributes to induction of an invasive, metastatic phenotype in carcinoma cells. In addition to basic molecular/biochemical cell techniques, the projects will exploit advanced techniques like genome-wide RNA interference screening, Solexa/Illumina deep-sequencing and mass-spec phosphoproteomics. The projects will be very collaborative, involving interactions with other scientists in the Frödin group and the Danish Centre for Epigenetics.
Please find more information about the position, salaries, qualifications and how to apply on www.bric.dk
