Postdoctoral Training Fellow
Structural Biology of Hsp90 Complexes
Section of Structural Biology
ICR
Chester Beatty Laboratories
Chelsea, London
The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organization receiving the highest rating in the 2008 RAE. In partnership with The Royal Marsden NHS Foundation Trust, we form the largest comprehensive cancer centre in Europe, dedicated to research that extends from world leading basic science in epidemiology, genetics and structural and molecular biology, through drug discovery and development, to cancer diagnosis and patient treatment.
A Wellcome Trust-funded Postdoctoral position is available from 1st October 2009 in the laboratory of Professor Laurence Pearl FRS, in the Section of Structural Biology, to study the structural basis for regulation and activation of ‘client’ proteins by the Hsp90 molecular chaperone system. The Postdoc will be responsible for expression, purification, crystallization and structural analysis of protein complexes involving the Hsp90 molecular chaperone, its co-chaperones and client proteins that depend on Hsp90 for their biological function.
The Section of Structural Biology at ICR is exceptionally well equipped for all aspects of modern structural biology, with state-of-the-art laboratories for molecular biology, recombinant expression in bacterial and eukaryotic systems, biochemistry, X-ray crystallography and electron microscopy. Excellent synchrotron access (~ 2 days/month) is available through rolling beam allocation programmes at Diamond and ESRF. Applicants must have a PhD, and experience in recombinant expression, protein purification, crystallisation and X-ray crystallography. Information on our previous work in this field can be found by searching PubMed and via the ICR Website http://www.icr.ac.uk/index.shtml
The starting salary for the position will be in the range £26,966 to £35,518 p.a. inclusive (based on previous post-doctoral experience) and the post is offered initially on a fixed term contract of up to 2 years. Informal enquiries can be made to Professor Laurence Pearl (laurence.pearl@icr.ac.uk). Please note – this address is for enquiries ONLY and applications must be submitted in line with the instructions below.
For further details of how to apply, as well as a job description and person specification, please visit our website at: http://www.icr.ac.uk/jobs.html. Alternatively, you may call our 24 hr recruitment line on 020 7153 5475 quoting reference C219.
Closing date: 8 May 2009
