地点: 美国 发布时间:2013-09-17 11:26:01 |
Applications are invited for postdoctoral positions at Cold Spring Harbor Laboratory (CSHL) from highly enthusiastic individuals with strong interest in utilizing structural, electrophysiological, and biochemical approaches to study fundamental problems in ion and substrate transports and enzymatic processes occurring at the membrane. Our goal is to understand molecular basis for synaptic transmission and neurological disorders and diseases. We use x-ray crystallography to obtain atomic structures of target membrane/glyco proteins and test structure-based functional hypotheses by various techniques including electrophysiology, analytical centrifugation, and fluorescence assay. We are equipped with a state-of-the-art facility to conduct membrane/glyco protein crystallography and functional studies including a high-throughput protein screening system, an automated crystallization screening device, a recently updated home x-ray source, electrophysiology rigs, and other setups such as isothermal titration calorimetry device.
CSHL is located in the suburb of New York City and is within 45 min driving distance from the National Synchrotron Light Source at Brookhaven National Laboratory. A highly collaborative environment at CSHL and the CSHLmeetings and courses provide a unique opportunity to interact with scientists from various fields within and outside of CSHL. Candidates must hold (or soon expect to hold) PhD in biochemistry, molecular biology, biophysics or related fields. Strong background in molecular biology, biochemistry, and large-scale protein expression in eukaryotic and prokaryotic cell-lines is required. Experience in x-ray crystallography or other techniques in structural biology, is highly desirable. Applicants with experiences in electrophysiology or cell biology in neuroscience or cancer biology are also welcomed. For more information, please check the laboratory website (http://www.cshl.edu/public/SCIENCE/furukawa.html) and contact me via email. Please send CV, a brief summary of research experience and interest, and three references to Hiro Furukawa by email at furukawa@cshl.edu
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