A fully funded postdoctoral position at Yale University School of Medicine is available immediately from highly motivated, enthusiastic individuals with a strong interest in the structure, function, and pharmacology of signaling proteins implicated in neurological and neuropsychiatric diseases. We are presently focusing our efforts on central nervous system transporters using a combination of steady-state kinetics, radioligand binding, and X-ray crystallography.
The laboratory is located in newly-renovated space in the Department of Cellular and Molecular Physiology in a highly collaborative environment. We have regular access to a Mosquito crystallization robot, LINUX* workstations, synchrotron beamlines, and an in-house X-ray generator with an R-axis IV++ detector. The lab’s proximity to the renowned W.M. Keck facility will additionally enable the successful candidate to conduct detailed experiments in static and dynamic light scattering, isothermal titration calorimetry, steady-state and stopped-flow fluorometry, and surface plasmon renonance.
Candidates must hold (or soon expect to hold) a Ph.D. in biochemistry, biophysics, or a related field. A strong background in recombinant DNA methods, protein expression and purification, and X-ray crystallography (including experimental phasing) is required. Prior work with membrane proteins, tissue culture, and functional assays is preferred but not necessary. The ideal candidate will also possess excellent oral and written communication skills and work well in a collaborative environment.
For more information, please contact me via e-mail. Interested applicants may also want to read the following review article:
Singh, S.K. (2008) LeuT: a prokaryotic stepping stone on the way to a eukaryotic neurotransmitter transporter structure. Channels. 2, 380-389
Applicants should send CV along with a one-page summary of previous research experience and arrange to have 3 reference letters sent to Dr. Satinder K. Singh via e-mail to satinder.k.singh@yale.edu
