University of Missouri-Columbia
Department of Medical Pharmacology and Physiology
My laboratory is currently recruiting postdoctoral fellows to work on the molecular basis for how endothelial cells assemble into tubes in 3D collagen matrices and stabilize following interactions with pericytes. We have also developed a research program focusing on vascular tube regression (and its relation to tumor anti-angiogenic therapy) which is complimentary to those centered on tube assembly. We use a combination of molecular and cell biological approaches using both in vitro and in vivo models to address the questions of interest. Ongoing potential projects include how integrins, Rho GTPases and matrix metalloproteinases coordinately control the ability of endothelial cells to form lumenal structures.
A second project focuses on how pericyte proteinase inhibitors such as TIMP-3 direct capillary tube stabilization, while a third project is utilizing our technologies to engineer microvascular networks in 3D matrices including both blood-derived and lymphatic endothelial cells. A fourth project focuses on the biological mechanisms underlying how endothelial cell derived MMP-1 and MMP-10 control vascular tube regression, while a fifth project addresses mechanisms controlling tumor cell dissemination into blood vessels and lymphatics during metastatic progression.
Address all inquiries along with a CV and a list of references to: George E. Davis, M.D., Ph.D. Professor, Department of Medical Physiology and Pharmacology, University of Missouri-Columbia, Columbia, MO 65212