Postdoctoral Positions are immediately available to study the mechanisms and function of signal transduction activated by chemoattractants and Wnts in the Vascular Biology Program and Department of Pharmacology, Yale University School of Medicine, New Haven, CT.
Chemoattractants play important roles in regulation of the immune functions and are key mediators of inflammatory responses. They are also involved in tumor metastasis. Wnt-activated signaling pathways regulate a wide range of physiological and pathophysiological processes, including embryonic development, organogenesis, bone remodeling, myogenesis, adipogenesis, tumorigenesis, and stem cell biology. We are currently using various biochemical, molecular and cell biological, genetic, proteomic, large scale RNAi screening, and transgenic and gene targeting approaches to: 1) characterize signaling pathways and networks of chemoattractants and understand mechanistic basis for chemotaxis of leukocytes, endothelial cells, and metastatic cancer cells; 2) elucidate Wnt signaling mechanisms, investigate the functions of Wnt signaling with regard to bone remodeling, diabetes, and stem cell biology. In addition, we are also exploring the therapeutic and research potentials of small molecule compounds we have identified using virtual “in silico” screening for altering Wnt and Dkk activity.
Please see our recent publications and webpage for detail: JCI 118:195-204, Science 315:1278, Science 314: 136, Nat Genet. 37:945, Nat. Cell Biol. 7:399, Mol. Cell Biol. 24:4677, Cell 114:215, New Eng. J. Med. 346;1513, Mol. Cell 7:801, Science 287:1046, PNAS 99;3603, EMBO J 18:4233; PNAS 96:10385; JBC 274:30419.
Competitive Salary and excellent work environment are offered. Self-motivated individuals with a Ph.D. trained in any area of biomedical sciences and particularly with experience in retrovirus and Lentivirus preparation and transduction and hematopoietic stem and progenitor cells are encouraged to apply. Send CV and names of three references to:
Dianqing (Dan) Wu, Ph.D.
Professor
Vascular Biology and Therapeutics
Department of Pharmacology
Yale University School of Medicine
P.O. Box 208089, Rm-337E
10 Amistad Street
New Haven, Connecticut 06520-8089
Email: dan.wu@yale.edu
