The Institute of Cancer Research
(University of London)
POST-DOCTORAL TRAINING FELLOW
Section of Structural Biology
The Institute of Cancer Research (a College of the University of London) is a world-class cancer research organization with HEFCE RAE ratings of international excellence across all of its research programmes. In partnership with The Royal Marsden NHS Foundation Trust, we form the largest comprehensive cancer centre in Europe, dedicated to research that extends from epidemiology, genetics and molecular biology, through drug discovery and development, to cancer diagnosis and patient treatment. This makes us uniquely placed to work towards our vision that people may live their lives free from the fear of cancer as a life threatening disease.
This Cancer Research UK funded position will investigate the structure and function of the Chfr protein (Checkpoint with Forkhead and RING domain), a ubiquitin E3 ligase and tumour suppressor involved in mitotic regulation. Chfr is crucial for a mitotic checkpoint that produces a cell-cycle delay in response to microtubule poisons. The successful applicant will determine crystal structures of Chfr bound to its protein partners and investigate the structural and cellular mechanisms of Chfr activity and regulation. The project is a collaboration between Dr Richard Bayliss (Structural Biology), Prof. Richard Marais (Cell and Molecular Biology) and Dr Spiros Linardopoulos (Breakthrough Breast Cancer).
Applicants must hold a PhD, or be close to completing their PhD studies, in biochemistry, molecular biology or structural biology. Experience in molecular biology, protein expression and purification is essential. Experience in crystallographic structure determination using SAD/MAD/MIR techniques would be considered an asset.
The position is offered on a fixed term contract of up to three years in the first instance with a starting salary in the range £26,597 to £31,551 p.a. inclusive.
Informal enquires may be made to Dr Richard Bayliss (Tel: +44 (0)20 7153 5557 / Email: email@example.com). Please DO NOT send your application to Dr Bayliss; CVs must be submitted in line with the instructions below.
For further particulars and details of how to apply, please visit our website at http://www.icr.ac.uk. Alternatively you may call our 24 hour recruitment line on 020 7153 5475 quoting reference number C128.
Closing date: Friday 4th April 2008