地点: 英国 发布时间:2013-09-17 02:28:11 |
Postdoctoral Research Assistant (ref. 13847)
Based in the Department of Physiology and Pharmacology, working in the laboratories of Dr Eamonn Kelly and Professor Graeme Henderson, the aim of this Wellcome Trust project is to study agonist-specific mechanisms of mu-opioid receptor (MOPr) desensitisation.
You will investigate the phenomenon of functional selectivity at MOPr. It is now thought that different agonists can induce different active conformational states of G protein-coupled receptors such as MOPr. This phenomenon, termed functional selectivity, may also extend to the process of MOPr desensitization with different agonists inducing desensitization by different molecular mechanisms. This may explain the differential ability of MOPr agonists such as morphine and DAMGO to induce tolerance to the euphoric and analgesic effects of these drugs in the intact organism. You will use a range of biochemical, molecular and pharmacological techniques to study the molecular basis for these differences. Given the timescale needed for completion of the project, you should already possess substantial experience in the relevant techniques. You should also have or be working towards a PhD in molecular neuropharmacology.
Further information can be found at:
http://www.bristol.ac.uk/phys-pharm/staffResearch/staffResearch.php?id=56
If successful, you may be appointed either on a fixed term or a permanent contract depending on the extent of your previous relevant research experience. Further information can be found at http://www.bristol.ac.uk/personnel/ftc/
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