地点: 英国 发布时间:2013-09-17 02:20:40 |
This post is available in the groups of Prof. A. P. Davis, School of Chemistry, and Dr. D. N. Sheppard, Department of Physiology and Pharmacology, on the EPSRC-funded project: “Synthetic Anion Carriers for Biomedical Applications”. Anion transport across membranes is a key biological process, vital for the health of cells and organisms. Dysfunctional anion transport (usually due to faulty anion channels) is the root cause of several genetic diseases, the most common being cystic fibrosis. Molecules which promote chloride transport across membranes could serve as treatments for these diseases, and would certainly be useful tools for research. We have developed a family of powerful anion receptors which show good activity as chloride transporters. In this new project we aim to understand and optimise the system, and to test the transporters in natural membranes and cells, with a view to developing therapeutic applications.
As part of the project team, we seek a membrane biophysicist or chemist who will play the major role in testing the transporters and characterising their mechanism of action. The main technique used will be electrical measurements in planar lipid bilayers (PLBs, or black lipid membranes), but the patch-clamp method will also be used to study transporters incorporated into giant liposomes. Studies in synthetic vesicles, and in natural membranes (patch-clamp electrophysiology and Ussing chamber technique), will also be performed. You will ideally have expertise in mechanistic studies of ion transport across natural and synthetic membranes using the PLB or patch-clamp techniques, and a background in either cell physiology or membrane chemistry. Experience in the study of synthetic ion transporters would be especially advantageous. You must be able to work closely with other members of the team, especially with a synthetic supramolecular chemist who will provide materials and collaborate on testing. The position is available for three years, subject to satisfactory progress. The starting date is negotiable, but must be no later than 31 October 2008.
For further information on the research groups see: http://www.chm.bris.ac.uk/staff/adavis.htm and http://www.bristol.ac.uk/phys-pharm/staffResearch/staffResearch.php?id=44
If successful, you may be appointed either on a fixed term or a permanent contract depending on the extent of your previous relevant research experience. Further information can be found at http://www.bristol.ac.uk/personnel/ftc/
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