地点: 美国 发布时间:2013-09-17 02:22:12 |
Gap junctions are prominent features that link immature cells in the nervous system of both invertebrates and vertebrates. However, little is known about the functional consequences of these interactions. We recently showed for the first time that signaling through gap junctions coordinates a network of cells to establish left-right asymmetry in the nervous system of C. elegans that is reflected in olfactory gene expression and function (Chuang et. al., Cell 2007). We are interested in understanding the molecular mechanisms of left-right neuronal asymmetry by this gap junction-dependent cell network. To learn more about the lab, please visit
http://www.cincinnatichildrens.org/research/div/dev-biology/fac-labs/chuang/
http://neuroscience.uc.edu/faculty/person.cfm?NeuroID=180
Applicants should have a Ph.D. degree (for less than three years) in genetics, cell biology, molecular biology, neurobiology, biochemistry or similar with experience in molecular biology techniques. Candidates with prior experience in electrophysiological recordings or calcium imaging or microarray are encouraged to apply. Interested and qualified candidates please send a brief cover letter describing research experience and interest, CV, pdf files of first-author publications from peer-reviewed journals, and names and contact information of at least two references to Dr. Chiou-Fen Chuang at Chiou-Fen.Chuang@cchmc.org.
References:
Gabel, C. V., Antonie, F., Chuang, C.-F., Samuel, A. D., and Chang, C. (2008). Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development 135, 1129-1136.
Chuang, C.-F., VanHoven, M. K., Fetter, R. D., Verselis, V. K., and Bargmann, C. I. (2007). An innexin-dependent cell network establishes left-right neuronal asymmetry in C. elegans. Cell 129, 787-799.
Chuang, C.-F. and Bargmann, C. I. (2005). A Toll-interleukin 1 repeat protein at the synapse specifies asymmetric odorant receptor expression via ASK1 MAPKKK signaling. Genes & Dev. 19, 270-281. (http://www.genesdev.org/cgi/content/full/19/2/270)
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