地点: 美国 发布时间:2013-09-17 02:22:33 |
A post doctoral position is available to study the effects of inducing a heat shock response (HSR) on the development of disease in a mouse model (EAE) of multiple sclerosis. This is an NIH funded project to investigate the molecular mechanisms by which a HSR is anti-inflammatory, inhibits Tcell responses, is neuroprotective, and modifies adult neurogenesis (J. Neurochem, 99, p. 1351-62, 2006; J. Neurosci Res 67, 461-70, 2002; J. Neurochem 85, 387-398, 2003).
Studies will make use of novel small molecular weight compounds to inhibit HSP90, and will explore the relative importance of client protein degradation versus induction of a HSR. The candidate should have experience in the EAE model or in analysis of Tcell activation, and knowledge of basic brain histological and Immunostaining methods. Other projects in the Feinstein lab include studies of stress responses and adrenergic signaling in the EAE model, in transgenic mouse models of AD, and in primary glial and neuronal cultures. Please send cv, description of research background, and letters of reference to: Dr Douglas L Feinstein, Department of Anesthesiology, 835 South Wolcott Street, MC513, Room E720, Chicago, IL 60612. email: dlfeins@uic.edu
The University of Illinois is an equal opportunity institution.
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