Position: We have an opening for an individual wishing to join a multidisciplinary project in the systems biology of inflammation. The successful candidate will be expected to perform proteomics analyses utilizing both quantitative intact proteomics and shot-gun methods on patient material from individuals with various inflammatory lung diseases. Applicants should have a Ph.D. in mass spectrometry (MS), bioanalytical chemistry, or a related field. We are especially interested in candidates with prior experience in respiratory related research.
Research: The overall project aims are to elucidate the mechanisms of chronic inflammatory diseases through integrated proteomics, genomics and metabolomics studies. The current opening concerns quantitative proteomics using both intact proteomics and shot-gun proteomics applications for profiling of bronchoalveolar lavage fluid (BALF), inflammatory cells and brush biopsies from the lung. As such, extensive experience in MS-based quantitative proteomics as well as MS applications for in-gel protein identification is central to this position. Experience with gel-based applications is a merit. The position also involves some aspects of methods development for quantitative proteomics, or supervision of such projects performed by graduate students in the lab. As such, an in-depth understanding of quantitative and statistical analyses is required. Developed methods will be employed in translational research to probe patient samples from a range of inflammatory conditions, including chronic obstructive pulmonary disease (COPD), asthma, and respiratory responses to inhaled environmental air pollutants. Studies will be performed in close collaboration with clinicians at the Karolinska Hospital. As part of the envisioned systems biology approach, proteomics and metabolomics data will be augmented with transcriptomics data collected at the University of California San Francisco Genomics Core Facility. Data will be incorporated into relational database structures and analyzed with omics-integrating bioinformatics tools and pathway maps in collaboration with the Kyoto University Bioinformatics Center (http://genome.jp/kegg/). The specific long-term aims of the project are to investigate the mechanisms of chronic inflammatory diseases from a systems biology perspective, towards the goal of developing novel interventions, treatments and therapeutics.
Environment: The Pulmonomics group at the Karolinska Institutet is affiliated to both the Division of Respiratory Medicine, Department of Medicine, and to the Karolinska Biomics Center. This double affiliation provides us with a unique opportunity to perform translational omics research on well-characterized clinical samples, which is the basis for our systems biology approaches to inflammatory lung diseases.
The Karolinska Institutet is one of Europe’s largest medical universities and contains commensurate resources and infrastructure. A total of 600 research groups span the full spectrum of medical disciplines and includes 2,000 researchers, 1,000 technicians, and 2,300 postgraduate students from all parts of the world who take part in both basic and clinical research.
Start date: Funding is available from February 2009, but the start date is negotiable. This position is initially available for 12 months, with potential renewal for an additional 12 months.
Salary: Salary is stipend-based, includes health insurance, and is negotiable depending upon applicant experience.
Applications: Send applications, including research experience, CV and at least two references to Åsa Wheelock (asa.wheelock@pulmonomics.net). Please write “Proteomics position” in the subject line of the email. Deadline for the application is January 31, 2009.
Further Information: For additional details, see: http://www.biomics.se/perspres.php?pers=120
