地点: 美国 发布时间:2013-09-17 02:36:17 |
My laboratory is currently recruiting postdoctoral fellows to work on the molecular basis for how endothelial cells assemble into tubes in 3D collagen matrices and stabilize following interactions with pericytes. We use a combination of molecular and cell biological approaches using both in vitro and in vivo models to address the questions of interest. Ongoing projects focus on the molecular mechanisms underlying how endothelial cells form lumens and tubes and this work has lead to the discovery of a signaling cascade downstream of the Rho GTPase, Cdc42, which controls this process. We investigate how Cdc42-dependent signaling interfaces with membrane type 1- matrix metalloproteinase (MT1-MMP), another critical molecule that is required for lumen and tube formation. In addition, using a novel model of endothelial cell-pericyte tube coassembly, we investigate how pericytes are recruited to tubes to affect endothelial cell tube stability, how they actively migrate along tubes to catalyze these events, and identify novel growth factor-mediated signals that control this stabilization process. Address all inquiries along with a CV and a list of references to: George E. Davis, M.D., Ph.D., Professor, Department of Medical Physiology and Pharmacology, University of Missouri-Columbia, Columbia, MO 65212
E-mail-:davisgeo@health.missouri.edu
The University of Missouri-Columbia is an equal opportunity/affirmative action employer and is designated a Doctoral/Research Extensive Institution by the Carnegie Foundation for the Advancement of Teaching. To request Americans with Disability (ADA) accommodations, please contact our ADA Coordinator at (573) 884-7278 (V/TTY).
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