Two NIH-funded postdoctoral positions are immediately available at Harvard Medical School & Immune Disease Institute. The fellows will study the mechanisms of integrin activation in the context of lymphocyte-endothelial and cancer-stromal cell interactions. We are particularly interested in candidates with prior experience in microRNAs, signaling, and/or, biochemistry.
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 2008. 319:627
The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008. 22:4109
Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest. 2007. 117:2526.
Applications should be sent to:
Motomu Shimaoka, MD, PhD
Immune Disease Institute
Harvard Medical School
See for further informationhttp://www.idi.harvard.edu/