Two NIH-funded postdoctoral positions are immediately available at Harvard Medical School & Immune Disease Institute. The fellows will study the mechanisms of integrin activation in the context of lymphocyte-endothelial and cancer-stromal cell interactions. We are particularly interested in candidates with prior experience in microRNAs, signaling, and/or, biochemistry.

 

Relevant publications:

 

Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 2008. 319:627

 

The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008. 22:4109

 

Aberrant activation of integrin alpha4beta7 suppresses lymphocyte migration to the gut. J Clin Invest. 2007. 117:2526.

 

Applications should be sent to:

 

Motomu Shimaoka, MD, PhD

 

Associate Professor

 

Immune Disease Institute

 

Harvard Medical School

 

(shimaoka@idi.harvard.edu)

 

See for further informationhttp://www.idi.harvard.edu/