A postdoctoral position is available in the laboratory of Dr. Antonio Sarikas at the Institute of Pharmacology and Toxicology (IPT), Technical University of Munich (TUM), Munich, Germany.
_Research in our lab focuses on the role of the ubiquitin-proteasome system (UPS) in cell signaling and growth regulation. _
The Cullin7 E3 ubiquitin ligase plays an important role in growth control and was linked to growth retardation syndromes in humans (1,2). Our laboratory has identified insulin receptor substrate-1 (IRS-1), a critical mediator of insulin and insulin-like growth factor 1 (IGF-1) signaling, as the proteolytic target of the Cullin7 E3 ligase (3).
The aim of this project is to study the role of Cullin7 mediated degradation of IRS-1 for growth regulation and its implication for CUL7 linked growth retardation syndromes.
Salary and 3 year-contract according to German TV